Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents

In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized.Based on docking results, multiple optimizations were made on the coumarin scaffold.Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and displayed obvious inhibitory Kitchen Boa effects on t

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Conspiracy beliefs and negative attitudes towards outgroups in times of crises: Experimental evidence from Germany.

While research on the determinants of conspiracy beliefs has been growing, there is still limited attention given to the broader consequences of conspiracy theories.This study examines the effects of conspiratorial framing on outgroup evaluations in the context of societal crises.Using an experimental design and a large representative sample of the

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Ultrasound-Guided Popliteal Artery Cannulation: An Alternative for Emergency Arterial Cannulation During Prone Position

Arterial cannulation Banana is an essential procedure for invasive blood pressure measurement as well as repeated arterial blood gas sampling in intensive care unit setting.Common sites for placing an arterial cannula are the radial artery, femoral artery, brachial artery, and dorsalispedis artery.In certain situations such as in the case of prone

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